职称/职务

副教授/系支部书记（兼副主任）

研究方向

主要研究方向为生物医药、生物化工：

1、药物新剂型与制剂创制技术

2、新型纳米前药设计与纳米诊疗体系构建

3、制药分离工程

邮箱

[email protected]

学习工作经历

2016/07-至今 安徽工业大学，bet365中国备用网址 化学生物学与制药工程系，讲师、副教授

2013/09-2016/07中国药科大学，制药工程学专业，博士

2010/09-2013/07中国药科大学，生物化工专业，硕士

2006/09-2010/07江南大学，生物工程专业，学士

主要科研项目及成果

主持国家重点研发计划任务等国家级及省部级以上课题3项，发表SCI、EI论文二十余篇，授权国家发明专利十余项。主要从事化学生物学与制药工程相关专业课程教学与科研，累计指导学生参加全国大学生制药工程设计竞赛获得全国二等奖3项、全国三等奖5项，国际互联网+大学生创新大赛（中国国际大学生创新大赛）获得国家级金奖1项、银奖1项、省级金奖3项。

热忱欢迎具有化学化工、材料、生物医药及相关交叉学科背景的研究生、本科生加入研究团队。课题组与国内双一流高校等研究机构保持了密切合作关系，可推荐或联合培养方式到相关课题组继续深造。实验室科研经费充足，除提供优厚的助研金，根据其科研成果给予一定奖励。欢迎有意向的同学与我们联系, Email:[email protected]。

近期承担项目经历：

1、国家重点研发计划政府间国际科技创新合作重点专项任务（2023YFE0110100），2023.10-2026.10，主持。

2、安徽省教育厅重点研究项目（2023AH051127），2023.7-2025.7，主持。

3、安徽省自然科学基金（2108085QB85），2021.1-2022.12，主持。

4、产学研项目（RH2300000567），2023.5-2025.5，主持

近期发表的科研论文:

[1] Tingyuan Yan, Wei Yuan, Linxiao Zhang, Zhiyu Li, Jinlei Bian, Davaadagva Damdinjav, Buyankhishig Dorjsuren, Alexander Valeryevich Finko, Yanliang Ren, Deqiang Wang,Tingxuan Yan*, Zhixiang Wang*, Natural flavonoid glycoside-based self-assembled nanoparticles for synergistic antibacterial activity and improved antioxidant properties, Natural flavonoid glycoside-based self-assembled nanoparticles for synergistic antibacterial activity and improved antioxidant properties, Journal of Drug Delivery Science and Technology, 2025, 105, 106583.

[2]Tingxuan Yan*,Jiahao Sua, Tingyuan Yan, Jinlei Bian, Ahmed R. Alic, Wei Yuana, Linping Wei, Yu Wanga, Mengting Gao, Qiang Ding, Lei Bi, Shuangshou Wang*, Xinya Han*,Self-Supply of Hydrogen Peroxide by a Bimetal-Based Nanocatalytic Platform to Enhance Chemodynamic Therapy for Tumor Treatment, Nanotechnology, 2025, 36, 045101.

[3] Shuangshou Wang, Jianing Hui, Yangrui Si, Tianyou Geng, Chunyan Yang, Yanshang Kang*, Daojin Li, Mingfu Ye,Tingxuan Yan*, Caibo Yue*, Deep-eutectic solvent coated paper: A reusable multi-purpose device for rapid visualization, adulteration identification, efficient removal and recycling of dyes in both food and environmental samples, Microchemical Journal, 2025, 209, 112625.

[4] Changling Lv, Shuang He, Gui He, Xianming Xiong, Congcong Wang, Yanliang Ren, Xinya Han,Tingxuan Yan*, Zhixiang Wang*, Preparation of indapamide-HP-β-CD and indapamide-PVP nanoparticles by supercritical antisolvent technology: Experimental and DPD simulations,The Journal of Supercritical Fluids,2024,209, 106262.

[5] Xiangxiang Wang, Shuang He, Kaiye Wang, Xin Wang, Tingyuan Yan,Tingxuan Yan*, Zhixiang Wang*, Fabrication of betamethasone micro- and nanoparticles using supercritical antisolvent technology: In vitro drug release study and Caco-2 cell cytotoxicity evaluation, European Journal of Pharmaceutical Sciences, 2023, 181, 106341.

[6] Congcong Wang, Tingyuan Yan,Tingxuan Yan*, Zhixiang Wang*, Fabrication of hesperetin/hydroxypropyl-β-cyclodextrin complex nanoparticles for enhancement of bioactivity using supercritical antisolvent technology, Journal of Molecular Structure, 2023, 1279, 134947.

[7]Tingxuan Yan*,Haili Wang,Xingfang Song,Tingyuan Yan,Yuwen Ding,Kang Luo,Juan Zhen,Gui He,Libin Nian,Shuangshou Wang*,Zhixiang Wang*, Fabrication of apigenin nanoparticles using antisolvent crystallization technology: A comparison of supercritical antisolvent, ultrasonic-assisted liquid antisolvent, and high-pressure homogenization technologies, International Journal of Pharmaceutics, 2022, 624, 121981.

[8] Shuangshou Wang*, Lu Zhang, Qiwen Jin, Zhongqiu Xu, Jiayi Zhao, Yuwen Ding, Wenzhi Li,Peng Lin, Jing Gu, Qi Zhang*, Yang Chen, Hongmei Chen,Tingxuan Yan*,Filter paper-based colorimetric analysis: An instrument-free strategy for semiquantitative naked-eye detection of food colorants, Food Chemistry, 2022, 390, 133087.

[9] Shuangshou Wang*, Yuwen Ding, Haili Wang, Wenzhi Li, Wenjing Xu, Panwen Sun, Wei Huang, Yang Chen*, Jing Gu, Peng Lin, Liang Ma, Zi Liu, Qiang Ling, Qi Zhang, Hongmei Chen,Tingxuan Yan*, Molecularly imprinted upconversion nanoparticles for active tumor targeting and microinvasive photothermal therapy, Journal of Materials Science, 2022, 57, 5177-5197.

[10]Tingxuan Yan, Yuting Tao, Xiangxiang Wang, Changling Lv, Guizhi Miao, Shuangshou Wang*, Deqiang Wang*, Zhixiang Wang*, Preparation, characterization and evaluation of the antioxidant capacity and antitumor activity of myricetin microparticles formated by supercritical antisolvent technology, The Journal of Supercritical Fluids, 2021, 175, 105290.

[11]Tingxuan Yan*, Mengru Ji, Yuxi Sun, Tingyuan Yan, Jie Zhao, Huiwen Zhang, Zhixiang Wang*, Preparation and characterization of baicalein/ hydroxypropyl-β-cyclodextrin inclusion complex for enhancement of solubility, antioxidant activity and antibacterial activity using supercritical antisolvent technology,Journal of Inclusion Phenomena and Macrocyclic Chemistry, 2020, 96, 285–295.

[12] Tingyuan Yan, Yi Zhang, Mengru Ji, Zhixiang Wang,Tingxuan Yan*,Preparation of irbesartan composite microparticles by supercritical aerosol solvent extraction system for dissolution enhancement, The Journal of Supercritical Fluids, 2019, 153, 104594.

第一发明人专利

[1]一种超临界压缩流体沉淀法制备雷公藤红素纳米颗粒的方法, ZL201810082477.7 专利授权

[2]吗啡啉类酸性离子液体在超临界压缩流体沉淀法制备黄芩素微胶囊中的应用, ZL201710455554.4专利授权

[3]一种黑枸杞中总黄酮、提取方法、应用, ZL201911288532.9专利授权

[4]一种超声协同高压均质技术制备芹菜素超细颗粒的方法, ZL202111239933.2 专利授权

[5]一种枇杷叶提取物纳米胶囊、制备方法及应用, ZL201911274027.9 专利授权

[6]一种硼酸功能化CdTe量子点及肿瘤靶向诊疗一体化复合纳米药物, ZL202311122035.8专利授权

[7]自供给过氧化氢的双金属基纳米凝胶及其制备方法和应用，CN202311280719.0，专利公开

[8]HPLC法检测L-谷氨酸中异构体杂质的装置及方法，

CN202410492821.5，专利公开